Rifampin and increase of warfarin dose: A case report and review of the literature / 中国药学杂志

ABSTRACT

OBJECTIVE: To report an actual case and doing a review about the interaction of warfarin and rifampin to provide a regimen about the combination of the two drugs. METHODS: Discribed a case and analyzed it, while access to relevant literature review. RESULTS: With concurrent use of rifampin, the dose of warfarin increase to 84 mg · week-1 when targeted INR reached. The available literature suggest that when the two drug concurrent used, warfarin doses may increase for several folds, once discontinue rifampin the warfarin dose should be decreased and more INR tests were needed. CONCLUSION: For patient taking rifampin at the same time, the warfarin dose would increase according to the INR, the genetic test may be helpful; when warfarin is discontinued, the warfarin dose may decrease and INR test may increase to get a efficacy and safety anticoagulation therapy.