Limit test of camphor and content determination of borneol in guanmaining tablets / 中国药学杂志

ABSTRACT

OBJECTIVE: To establish a method for the quality control of borneol in Guanmaining tablets. METHODS: Gas chromatography was used for the quantitative determination of borneol and isoborneol and the test of camphor. FID was used as detector and HP-INNOWAX column (30 m×0.25 mm, 0.25 μm) was used as the stationary phase. Column temperature was increased by programming from the original temperature of 120℃ to 180℃ at the rate of 20℃·min-1 and kept for 7 min. RESULTS: Borneol, isoborneol and camphor showed good linear relationships in the ranges of 3. 980 μg·mL-1-1.990 mg·mL-1, 4.012 μg·mL-1-2.051 mg·mL-1, 4.170 μg·mL-1-0.2085 mg·mL-1, respectively. The average recoveries were 100.10% (n=6, RSD=1.6%) for borneol, 98.21% (n=6, RSD=1.8%) for isoborneol, and 101.00% (n=6, RSD=1.3%) for camphor, respectively. CONCLUSION: The method is simple, accurate, and rapid, and can be used for the quality control of borneol in Guanmaining tablets.