Clopidogrel resistance and ABCB1 (3435C >T) gene polymorphism: a meta analysis / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the association between clopidogrel resistance (CR) with 3435C >T site polymorphism of ABCB1 gene. METHODS: The published articles were searched in the Pubmed, Science direct, Wiley online library, Web of Science, CNKI, CDDB database, and VIP. Search and sort out the article which is clopidogrel-resistance/clopidogrel-efficacy(CE) study about the relationship between CR and 3435C > T site polymorphism of ABCB1 gene, also combined with manually retrieving the references and similar results in the attached documents. The range of searching time was all from inception to June 25, 2014. RevMan5.0 software was used to conduct the Meta-analysis and other statistic analysis. RESULTS Six articles were included in our research. It showed that the total number of CR is 2 619, and the total number of CE is 2 799. While the result showed that there exist significant correlations between ABCB1 3435C >T loci polymorphism and CR in the allele gene model, dominant gene model, co-dominant gene model (CC/CT) and super-dominant gene model; the allele gene model, OR = 1.27, 95% CI (1.13, 1.42); dominant gene model, OR = 1.42, 95% CI (1.22, 1.65); co-dominant gene model (CC/CT), OR = 1.43, 95% CI (1.20, 1.69); super-dominant gene model, OR = 1.30, 95% CI(1.11, 1.52). The further race subgroup analysis showed that there possess significant relevance between ABCB1 3435C >T loci polymorphism and CR in Asia (P T loci polymorphism among European; but CR relates to the ABCB1 3435C > T loci polymorphism among Asian.