Content determination method of crotamiton / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1721-1725, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-859673
ABSTRACT
OBJECTIVE:
To study the content determination method of crotamiton.METHODS:
The quantitative mass balance method, HPLC external standard method and nuclear magnetic resonance (QNMR) were used to determine the content of crotamiton, respectively.The accuracy of the three methods was evaluated.RESULTS:
The contents of crotamiton were 99.2%, 102.9% and 99.1% respectively as determined by the three different methods.CONCLUSION:
Because the ultraviolet absorption coefficients of cis- and trans-crotamiton might be different, the current pharmacopoeia method, ie, using integrated peak areas to calculate the content, is questionable. QNMR method can measure the contents of cis- and trans-crotamiton respectively, so it can be a complementary method to establish the reference standard.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2015
Type:
Article
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