Retrospective analysis of the clinical rational drug use refer to NCCN antiemetic guideline / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the application of antiemetics in patients with gynecological cancers during chemotherapy. METHODS: Medical records of 182 patients receiving chemotherapy lor gynecological cancer were evaluated and a descriptive a-nalysis was carried out.Logistic regression was performed to determine the predictors of compliance. RESULTS: The rate of adherence to guideline (CINV) for patients receiving one-day chemotherapy is 80%. prophylactic usage rate in patients receiving multi-days chemotherapy is 95%, with a 47% 5-HT3 receptor antagonist.The adherence to NCCN anti-emesis guideline was better in patients having paclitaxel-based chemotherapy than patients having no paclitaxel. CONCLUSION: As the biggest cancer hospital in China, antiemetics were commonly given as prevention of CINV in the form of 5-HT3 receptor antagonist, but antiemetic effect of dexametha-sone was ignored and needed to be emphasized.