Study on pharmacodynamics and biodistribution of vinorelbine bitartrate thermosensitive liposomes / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the tissue distribution and pharmacodynamics of vinorelbine bitartrate thermosensitive liposomes. METHODS: Subcutaneous xenotransplanted tumor model of human ovarian carcinoma SK-OV-3 in nude mice was established. The tumor inhibitory efficacy and biodistribution of drug were evaluated in nude mice by intravenous ad-minstration with vinorelbine bitartrate thermosensitive liposomes and vinorelbine bitartrate injection. RESULTS: The inhibition rate of vinorelbine bitartrate thermosensitive liposomes was remarkably higher than that of injection at same dose. Moreover, The drug concentration in heated tumor of mice administrated with vinorelbine bitartrate thermosensitive liposomes was a-bout 4 fold compared with that of mice administrated with injection. CONCLUSION: Vinorelbine bitartrate thermosensitive liposomes combined with hyperthermia could significantly increase drug concentration in local tumor tissue and promote tumor inhibitory efficacy.