Development of therapeutic drug monitoring software of vancomycin for adult patients / 中国药学杂志

ABSTRACT

OBJECTIVE: To develop a therapeutic drug monitoring software of vancomycin for adult patients to help physician for personalized use of vancomycin. METHODS: A system literature retrieval search was conducted in the PubMed database to collect the population pharmacokinetic studies published before September 2012. A set of therapeutic drug monitoring models for vancomycin was assembled by the models included in the above literatures and the model developed by the authors. Based on the Bayesian principle, a therapeutic drug monitoring software built upon these population pharmacokinetic models was developed with C++ in the integrated development environment (Microsoft Visual Studio 2005). RESULTS: The set of therapeutic drug monitoring models included 14 population pharmacokinetic analyses. The software developed on these pharmacokinetic models could be applied to conduct population, subpopulation and individual predictions, thus help clinician in their individualized treatments. CONCLUSION: This study developed software covers the current reported vancomycin pharmacokinetic model. Clinician can choose the appropriate model according to the actual situation of the patients.