Effects of Fufangbiejiaruangan tablet compound prescription on intestinal absorption of paeoniflorin / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the intestinal absorption characteristics of three components (paeoniflorin, phillyrin, ginsen-osides Rg1) of Fufangbiejiaruangan tablets and the effects of prescription on the intestinal absorption of paeoniflorin. METHODS: Everted intestinal sac method was adopted to mimic the intestinal absorption process of Fufangbiejiaruangan tablets extract at three concentrations. The intestinal absorption mechanisms of paeoniflorin, phillyrin and ginsenoside Rg1 were studied. HPLC assay was used to determine the three components and the time-accumulative absorption curves were drawn to compare the absorption characteristics of paeoniflorin in the prescription preparation and paeoniflorin solution. RESULTS: The absorption of the three components was linear at different intestinal segments and doses, and the correlation coefficients of the regression equations were all more than 0.9 (r≤0.9), which were consistent with zero order rate process. The Ka(s) of the components increased along with the increasing dosage, which indicated passive absorption. The cumulative absorption rate of paeoniflorin in Fufangbiejiaruangan tablets was better than one-component solution. CONCLUSION: The compatibility of Fufangbiejiaruangan tablets is beneficial to paeoniflorin absorption and ginsenoside Rg1 may be the indicator of the quality standard of Fufangbiejiaruangan tablets.