Preparation and quality evaluation of paclitaxel self-microemulsifying drug delivery system / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 485-489, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-859799
ABSTRACT
OBJECTIVE:
To prepare paclitaxel self-microemulsifying drug delivery system (PTX-SMEDDS) and evaluate its quality.METHODS:
The equilibrium solubility of paclitaxel in different compositions of oil, emulsifiers and assistant emulsifiers was investigated. The optimal Km was determined and PTX-SMEDDS was prepared by using the method of titration to establish the pseudo-tern, injury phase diagram. The appearance, morphology, size distribution, concentration and stability of PTX-SMEDDS were determined.RESULTS:
PTX-SMEDDS prepared with EL-35, lecithin and anhydrous ethanol at the ratio of 416, containing 6% DOC-Na and 7.5% of MCT, was a uniform and stable colloidal system displaying as a translucent diluted-yellow solution. PTX-SMEDDS under elec-from microscopy consisted of small spherical drops with a mean diameter of 19.4 nm. The appearance, pH, concentration and particle size of SMEDDS were stable after it was diluted with sodium chloride injection and glucose injection by 10-fold or 50-fold, respectively.CONCLUSION:
The PTX-SMEDDS is easy to prepare and its quality is stable, which provieds some information for the development of new paclitaxel formulations.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2014
Type:
Article
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