Use of nonsteroidal antiinflammatory drugs in patients with cardiovascular disease / 中国药学杂志

ABSTRACT

OBJECTIVE: To provide appropriate guidelines to optimize the rational use of nonsteroidal anti-inflammatory drugs (NSAIDs) for patients with established cardiovascular disease (CVD). METHODS: Mechanisms of increased CVD risk due to NSAIDs were elaborated. Results of clinical researches and Meta-analysis for different NSAIDs in CVD risk were reviewed. RESULTS: All NSAIDs are associated writh an increased risk of cardiovascular adverse effects. The degree of selectivity for cyclooxygenase-2 and the interaction with low-dose aspirin may contribute to the CVD risk of different NSAIDs. CONCLUSION: Physicians should weigh the benefits against risks for individual patients with CVD. NSAIDs should be used in strict accordance with indications and contraindications. Appropriate class of NSAIDs should be selected and interaction with aspirin should be avoided in patients with CVD. After the prescription of NSAIDs, the patients should be monitored to minimize the adverse effects.