Research progress of Bcl-2 regulating autophagy in myocardial ischemia-reperfusion injury / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the relationship between myocardial ischemia-reperfusion injury and Bcl-2 family proteins regulating autophagy were searched, and elaborated the mechanism of Bcl-2 family proteins affecting myocardial ischemia-reperfusion injury by regulating autophagy. METHODS: The literatures which related to myocardial ischemia-reperfusion injury and Bcl-2 family proteins regulating autophagy were searched. The review is finished by analyzing and organizing the literatures. RESULTS AND CONCLUSION: In early ischemia, appropriate autophagy of myocardial cells can reduce the degree of ischemia-induced myocardial injury, however, in the reperfusion period, excessive activation of autophagy can aggravate myocardial cell injury. Bcl-2 family proteins are important regulation factors of autophagy, it can play an important role by interacting with other relevant factors contained in autophagy pathway during the two different periods of myocardial ischemia and reperfusion injury.