Advances in the structural modification study of CDDO and its derivatives / 中国药学杂志

ABSTRACT

OBJECTIVE: To systematically summarize studies on the synthesis of 2-cyano-3, 12-dioxoolean-l, 9-dien-28-oic acid (CDDO), structural modification and structure-activity relationship(SAR) of CDDO and its derivatives in the positions of A, C rings, C-2, C-17 and others. METHODS: Based on the newest research reports at home and abroad, the SARs of CDDO and its derivatives were analyzed and summarized. RESULTS AND CONCLUSION: SAR studies of CDDO and its derivatives can help us use them as references for the development of drugs with better actitivity and selectivity.