Research progresses of multivesicular liposomes in delivery of protein and peptide drugs / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 94-98, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-859863
ABSTRACT
OBJECTIVE:
To provide a review of the research progresses of the multivesicular liposomes as a carrier of the protein and peptide drugs.METHODS:
To summarize and analyze the researches of the protein/peptide drugs encapsulated in multivesicular liposomes according to the related articles. RESULTS ANDCONCLUSION:
A major problem in the clinical usage of protein and peptide drugs is frequent injection, for they have poor stability, short half-life time and high clearance. This challenge has been successfully met by the multivesicular liposomes encapsulating the peptide and protein drugs. The new liposome uses depot foam technology to achieve high loading sufficient and encapsulation, and they are very competent carriers of the compounds, especially the water-soluble drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2014
Type:
Article
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