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Chemical constituents of a marine fungus Nigrospora sphaerica / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 26-29, 2014.
Article in Chinese | WPRIM | ID: wpr-859885
ABSTRACT

OBJECTIVE:

To study the chemical constituents of the mycelium of a marine microorganism Nigrospora sphaerica.

METHODS:

Compounds were extracted and isolated by silica gel column chromatography, Sephadex LH-20 column chromatography and HPLC techniques and identified by spectroscopic analysis.

RESULTS:

Eleven compounds were isolated and identified as ergosta-5, 7, 22-triene-3β-ol(1), cholesterol(2), pyrrolopiperazine-2, 5-dione [cyclo-(Pro-Gly)](3), 3-methylpyrrolopiperazine-2, 5-di-one [cyclo-(Pro-Ala)](4), 3-benzylpyrrolopyrazine-2, 5-dione [cyclo-(Pro-Phe)](5), 3-benzyl-piper-azine-2, 5-dione [cyclo-(Gly-Phe)](6), 5-(hydroxymethyl)furan-2-carbaldehyde(7), leucine(8), 3, 6-dimethylpiperazine-2, 5-dione [cyclo-(Ala-Ala)](9), adenine(10) and uridine(11).

CONCLUSION:

Compounds 1, 3-7 and 11 are obtained from Nigrospora sphaerica for the first time.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2014 Type: Article