Prepartion and performance in vitro of a novel p-aminomethyl benzoicacid and calcium alginate microspheres of rifapentine / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare p-aminomethylbenzoic acid and calcium alginate composite microspheres with rifapentine as model drug, and characterize and evaluate the drug release performance. METHODS: The high-voltage electrostatic liquid drop device was used to prepare the P-aminomethylbenzoic acid and calcium alginate microspheres of rifapentine. The particle size, loading efficiency, entrapment efficiency, swelling ratio and drug-releasing of the microspheres were measured. RESULTS: The particle size of the microspheres was 163.12 μm, the loading efficiency and entrapment efficiency were 51.5% and 89.3% Respectively. The swelling rate was 19 after swelling 70 h in saline, the total drug release rate was 75% after 120 h in saline under the condition of 37°C and 150 r·min-1. CONCLUSION: The addition of p-aminomethylbenzoic acid slows down the fast-corrosion of calcium alginate microspheres in saline, improves the drug release properties.