Preparation and in vitro mucosal penetration evaluation of ph-sensitive thiolated chitosan nanoparticles for low molecular weight heparin delivery / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1414-1419, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-859912
ABSTRACT
METHODS:
The pH-sensitive thiolated chitosan nanoparticles were prepared by ionic cross-linking reaction and characterized for the shape, particle size, Zeta potential, drug entrapment efficiency and loading capacity. In vitro release of low molecular weight heparin from the prepared nanoparticles was evaluated in 0.1 mol•L-1 HCl solution and phosphate buffered saline (PBS) at pH 6.8 using the dialysis method. The intestinal permeability was estimated utilizing Franz diffusion cell system.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2014
Type:
Article
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