Effects of inotodiol on apoptosis and cell cycle of HeLa cells in human cervical cancer / 中国药学杂志

ABSTRACT

CONCLUSION: Inotodiol isolated from Inonotus obliquus induced apoptosis and cell cycle arrest at G1 phase in vitro. The mechanisms may be related to promoting apoptosis through increasing the expression of bax and cutting bcl-2 and affecting the cell cycle by down-regulation the expression of cyclin E and up-regulation of p27. The results further indicate the potential values of inotodiol for the treatment of human cervical cancer.