Preparation of vinorelbine tartrate liposomes injection by different methods and their properties and antitumor effects / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1333-1337, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-859952
ABSTRACT
RESULTS:
All EEs of the three VLIs were over 93%. The mean diameters, Zeta potentials and entrapment efficiencies of the three VLIs were similar. Meanwhile the three VLIs were stable in the long-term stability test. The cryo-TEM showed that almost all vesicles had spherical structure and uniform nanosize. Furthermore, some colloid substances and acicular crystal were found inside VLI-2 and VLI-3, respectively. The release rate of VLI-3 was slower, which indicated that the drug crystal probably influence the in vitro drug release. The pharmacodynamic test showed that the antitumor effect of VLI-3 was better than VLI-2 and VLI-1, while those of the latter two were superior to VI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2014
Type:
Article
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