Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
Kidney Research and Clinical Practice
;
: 222-225, 2014.
Article
in English
| WPRIM
| ID: wpr-86001
ABSTRACT
Toxic epidermal necrolysis (TEN) is a drug-related fatal disease. Extensive necrosis of the epidermis can lead to serious complications. This report describes two cases of TEN, associated with deflazacort (DFZ), in two boys, aged 4 years and 14 years, with nephrotic syndrome (NS). The 14-year-old male teenager received DFZ following NS relapse. After 17 days, pruritic papules appeared on the lower extremities. Another case involved a 4-year-old boy receiving DFZ and enalapril. After a 41-day DFZ treatment period, erythematous papules appeared on the palms and soles. Within 3 days, both boys developed widespread skin lesions (>50%) and were admitted to the intensive care unit for resuscitative and supportive treatment. The patients showed improvement after intravenous immunoglobulin-G therapy. Owing to the rapid, fatal course of TEN, clinicians need to be aware of the adverse effects of this drug when treating cases of NS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Skin
/
Enalapril
/
Stevens-Johnson Syndrome
/
Lower Extremity
/
Epidermis
/
Intensive Care Units
/
Necrosis
/
Nephrotic Syndrome
Limits:
Adolescent
/
Child, preschool
/
Humans
/
Male
Language:
English
Journal:
Kidney Research and Clinical Practice
Year:
2014
Type:
Article
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