Synthesis and characterization new pH-sensitive Chitosan-Ketoprofen drug and exploration its drug release properties / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare the new drug chitosan-ketoprofen (CTS-KPF), and evaluate its characteristics in vitro release. METHODS: The drug ketoprofen (KPF) molecules was grafted to the molecular chain the linear polymer chitosan (CTS) by homogeneous liquid phase method, preparing the new drug CTS-KPF. The fourier transform infrared spectrum (FT-IR) and the nuclear magnetic resonance spectroscopy (CP/MAS13 C-NMR, 1H-NMR) was used to characterize the structure CTS-KPF; the scanning electron microscopy (SEM) was used to observe the CTS-KPF apparent morphology; the X-ray diffraction (XRD) was used to study the change crystallinity CTS-KPF and the ultraviolet-visible spectrophotometry (UV-Vis) was used to analyze the drug release performance under different pH conditions and establish the model CTS-KPF releasing drug in vitro. RESULTS: The synthetic route is reasonable and the CTS-KPF new pH-sensitive drug was synthezed successfully. The FT-IR, CP/MAS13 C-NMR, 1H-NMR, SEM and XRD verified the chemical reaction mechanism and the molecular structure CTS-KPF. The CTS-KPF drug release performance in simulated body fluid indicates that the CTS-KPF has desired pH-sensitive and it tend to release in low pH simulated gastric fluid. CONCLUSION: CTS-KPF is a pH-sensitive polymer drug, the results can provide a reference for the research pH-sensitive polymer smart drugs based on CTS.