Progress in research of biorelevant dissolution media / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 2084-2088, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-860107
ABSTRACT
OBJECTIVE:
To summarize and analyze the physiological parameters of the gastrointestinal tract, as well as the progress in research of biorelevant dissolution media.METHODS:
Related literatures in recent years were reviewed.RESULTS:
The biorelevant dissolution media based on physiological relevant information were used to establish the methods of dissolution evaluation in vitro.CONCLUSION:
With depth understanding of the physiological parameters of the gastrointestinal tract, in vitro dissolution of dosage form in biorelevant dissolution media could predict in vivo dissolution performance. In addition, biorelevant media were utilized to investigate the food effect on dissolution. Therefore, the liability of evaluating in vitro-in vivo correlation is further improved.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2014
Type:
Article
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