Pharmacodynamics of recombined human glucagon-like peptide-1 in Chinese type 2 diabetic patients / 中国药学杂志

ABSTRACT

OBJECTIVE: To evaluate the pharmacodynamics of recombined human glucagon-like peptide-1 (GLP-1) after multiple dose subcutaneous injection with or without oral dimethyl diguanidine in Chinese type 2 diabetic patients. METHODS: Twenty-four Chinese type 2 diabetic patients were divided into three groups randomly to receive multiple dose of GLP-1 with or without oral dimethyl diguanidine. Plasma samples were collected after injection. The concentrations of glucose and insulin were determined, and the variation of glucose and insulin was analyzed. RESULTS: There was a significant reduction of blood glucose level compared with base line within 2 h after injection of GLP-1. The reduction magnitudes in the three groups were in the following sequence GLP-10.2 mg + dimethyl diguanidine > GLP-10.2 mg > GLP-10.1 mg. There was a rise of insulin in contrast with base line within 10 - 30 min after injection of GLP-1. CONCLUSION: There are a rise of blood insulin and a reduction of blood glucose after injection of GLP-1 in Chinese type 2 diabetic patients.