Microbial transformation of Ursolic acid by Streptomyces griseus subsp. griseus CGMCC 4.18 / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1994-1997, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-860129
ABSTRACT
OBJECTIVE:
To modify the structure of Ursolic acid(UA), a pentacyclic triterpene acid, existing a variety of natural plants with extensive biological activities thus to increase the diversity of structure of UA and lay the foundation for screening more active compounds.METHODS:
The structure of UA was modified by Streptomyces griseus subsp. griseus CGMCC 4.18 by microbial transformation.RESULTS:
A rare hydroxylated at 2 position, product corosolic acid, 2α, 3β-dihydroxy-urs-12-en-28-oic acid which is difficult to obtain by chemical methods and the product 3, 4-seco-ursan-4-hydroxy-12-en-3, 28-dioic acid with cleavage of ring-A were yielded. Interesting, the hydroxylation at C-2 is α configuration that is rare. The structures of product were established based on spectroscopic data and reference compounds.CONCLUSION:
The structure diversity of ursolic acid was increased by microbial transformation by Streptomyces. Furteremore, microbial transformation illustrated regional selectivity and high stereo-selectivity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2014
Type:
Article
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