The preparation and evaluation of flurbiprofen axetil lipid microsphere injection / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare stable flurbiprofen axetil lipid microsphere for intravenous injection. METHODS: The optional formulation and prepared procedure were obtained through the single factor and crosscut design of experiment, and the stability constant of centrifugation Ke, particle size, Zeta potential, the pH of the product were studied. RESULTS: The optional formulation and procedure were 10% soybean oil for intravenous injection, 1.2% soybean lecithin, 0.6% F68, 0.4% oleic acid, 2.0% glycerol and 90% water for injection. pH was adjusted to 8.0 before homogenization and the sample was homogenized at a pressure of 80 MPa for 6 times. Finally, the lipid microspheres were sterilized for 15 min by sterilizing at 121°C and exhibited good stability after sterilization. The content of Flurbiprofen Axetil lipid microspheres was 95.59%. CONCLUSION: The preparation process is feasible to prepare lipid microsphere with good physical stability.