Effects of compound pollen typhae extract on rat models with nephritis hematuria / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the effect of compound pollen typhae extract on nephritis hematuria and renal function in rats, the pharmacodynamics evaluation laid a foundation for the development of hospital preparations compound pollen typhae granule. METHODS: The rat model of renal hematuria was induced by immunogen bovine serum albumin (BSA) gavages, carbon tetrachloride (CCl4) subcutaneous injection, and lipopolysaccharide (LPS) tail vein injection. Intragastric administration of high, medium and low-dose compound pollen typhae extract was performed for 6 weeks. Testing concentration of serum creatinine (SCr), urea nitrogen (BUN) and total protein (TP) in rat blood, and 24 h urine protein, urine creatinine quantitative, urine deformed erythrocyte number were detected in the fourth week and sixth week respectively. RESULTS: Compound pollen typhae extract reduced the urine deformed erythrocyte number, 24 h urinary proteins quantitative, cut down SCr and BUN, and increased TP and CCr, there are significant differences(P < 0.01 or P < 0.05). CONCLUSION: Compound pollen typhae extract is effective in the treatment of glomerulonephritis hematuria in rat model through improving renal function, with high dose group of best effect.