Preparation and quality evaluation of ibuprofen sustained release pellet capsules based on solid dispersion technology / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare ibuprofen sustained release pellet capsules based on solid dispersion technology and evaluate the quality. METHODS: Ibuprofen matrix sustained release pellets were prepared by fluidized-bed spray drying process, using blank pill core as based pills, stearic acid as isolation layer, and PVP as carrier material. The factors influencing the pellet release were studied, including coating dispersion, preparation method, and assay method of release. RESULTS: The prepared ibuprofen sustained release pellets had ideal controlled release and characteristics, including particle size, spherical degree, drug loading, and content. CONCLUSION: A new preparation method of ibuprofen sustained release pellets with advantages of less adjuvants, no deed to micronize crude drug, simple process, and controllable quality is successfully developed. It can be used in industrialized manufacture.