Problems and strategies of cationic polymer vector for brain-targeting gene delivery / 中国药学杂志

ABSTRACT

OBJECTIVE: Cationic polymers can deliver gene into brain and improve the impression of exogenous gene in brain tissues. This review elaborates the problems and strategies of cationic polymers tansfering gene into brain by cationic polymers, and provides a reference for further study. METHODS: The literatures about cationic polymers were searched, and the progress of cationic polymers as gene carrier from several aspects were analyzed and summarized such as vector construction, ligands modification, efficient improvement and toxicity reduction. RESULTS AND CONCLUSION: Cationic polymer vector has the advantage of high drug-loading, but it has to overcome the limits of BBB, high cell toxicity, low transfection and low targeting. It can be improved by structure reconstruction, ligand modification, and so on. Cationic polymer is relatively safe and high efficient, so it is capable of providing efficient approach of gene delivery.