Effect of Dendrobium officinale Kimura et Migo on substance metabolism and exercise capacity in rats after exercise training / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the effects of Dendrobium officinale Kimura et Migo on the rats substance metabolism and anti-exercise fatigue capacity in the exercise training. METHODS: High-intensity endurance training rat was as a model. Divided the 6-week-old male (42 d age) Wistar rats 55 into 5 groups of 10 (removed the rats, which are not meeting the requirement) still group (group C), exercise group (group T), exercise ig low-dose Dendrobium officinale Kimura et Migo group of (group TML), exercise ig middle-dose of Dendrobium officinale Kimura et Migo group (group TMM), exercise ig high-dose of Dendrobium officinale Kimura et Migo group (group TMH). Gavage using professional device ig once a day, group TML, Group TMM, group TMH ig dose was 1.5, 3, 4. 5 g · kg-1 · d-1, the ig volume 5 mL · kg-1, Group C and group T were added to ig the same amount of saline. For 24 h after the last training, measured weight, exhaustive swimming time, Hemoglobin and other biochemical markers. RESULTS: The TM each weight no significant differences, and greater than the group T(P < 0.05) less than group C(P < 0.05). TM swimming time is longer than the group C and group T(P < 0.01), and the dose increased and extended. Prolonged exhaustive exercise lead to liver glycogen, muscle glycogen reserves decreased(group T(P < 0.01), groups TM(P < 0.05) lower than in group C. TM each group of liver glycogen [P < 0.05), inositol the original (P < 0.01] higher than the group T, no significant differences between each group of the TM, with the dose increase and higher). In addition, blood urea nitrogen rise[group T(P < 0.01) and groups TM(P < 0.05) blood urea nitrogen higher than in group C. Groups TM is lower than the group T(P < 0.05), TM each non-significant difference]. Hemoglobin decreased [group T(P < 0.01), groups TM(P < 0.05) lower than in group C. Groups TM is higher than the group T(P < 0.05), no significant difference between the TM each]. CONCLUSION: Dendrobium officinale Kimura et Migo supplement can promote protein synthesis, inhibition of amino acid and protein degradation, thereby increasing the hemoglobin content and glycogen reserves, enhanced resistance to fatigue, it has a multi-target, multi-channel features.