Development of research on regulation mechanism of epigenetic modifications for drug metabolic enzymes / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1425-1428, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-860242
ABSTRACT
OBJECTIVE:
To make a review of nowadays related dissertations about epigenetic modifications (DNA methylation, histone modifications, chromatin remodeling and the non-coding microRNA interruption, etc.) mediating the abnormal expression of drug metabolic enzymes and inactive metabolism of substances in organisms.METHODS:
Researches on epigenetic modifications regulating the genes expression or activity change of drug metabolism enzymes were reviewed. RESULTS ANDCONCLUSION:
The research in this field can provide reference for determining biomarkers in clinical diagnosis and therapies of tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article
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