Influence of edaravone on postoperative cognitive function and cerebral oxygen metabolism in elderly patients undergoing spinal surgery / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the influrence of edaravone on postoperative cognitive function and cerebral oxygen metabolism in elderly patients undergoing spinal surgery. METHODS: One hundred and twenty patients, undergoing selective thoracolumbar surgery, aged 65 to 75 years old, were randomly divided in edaravone group(E) and control group(C) with 60 cases each. The group E was given edaravone 0.5 mg · kg while the same amount of saline in group C 30 min before the anesthesia indution. A battery of Mini-Mental state examination(MMSE) was administered day 1 before, day 1 and 4 d after surgery. Blood samples were taken from artery and internal jugular vein simultaneously for blood gas analyses immediately after anesthesia induction (t0), 1 h after anesthesia (t1) and the end of operation(t2). The aterial oxygen content (CaO2) jugular venous oxygen content (CjvO2), the difference of artery-jugular venous oxygen content (Da-jvO2) and the cerebral extraction rate of oxygen (CERO2) were calculated. RESULES MMSE scores were significantly lower in both groups after surgery. Compared with control group, the redution of MMSE score was obviously lower in edaravone group 1 d after surgery (P0.05). The incidence of POCD on the first day after surgery was lower in group E than that in group C(16.7% vs 26.7%) (P<0.05). Moreover, there were significantly differences between two groups in Da-jvO2 and CERO2 at t1 and t2. CONCLUSION: These data indicate that edaravone could reduce the occurence of early POCD in elderly patients which may be associated with improving the cerebral oxygen metabolism.