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Antioxidant activity and chemical constituents of Moghania philippinensis / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 1249-1254, 2013.
Article in Chinese | WPRIM | ID: wpr-860284
ABSTRACT

OBJECTIVE:

To investigate the chemical constituents of antioxidative fractions in roots of Moghania philippinensis (Merr. et Rolfe) Li..

METHODS:

The antioxidant activities of the extract and fractions were evaluated by determining their ability to scavenge DPPH radicals. The compounds were isolated by chromatographic techniques with silica gel, Sephadex LH - 20 and semi-preparative HPLC. Their structures were identified by analysis of physical and spectral evidence, and confirmed by comparison of their spectral data with reported values in the literature or those of authentic samples.

RESULTS:

The chloroform and n-butanol extracts showed strong scavenging activity against 2, 2-diphenyl-l-picrylhydrazyl(DPPH). Twenty-one compounds were isolated and identified as palmitic acid(1), lupeol(2), β-sitosterol(3), 3', 4'-dihydroxy-trans-cinamic acid tetracosyl ester(4), 3-(4-methoxyphenyl) propionic acid(5), n-tetracosanoic acid(6), 5, 7-dihydroxy-6, 8-diprenylchromone(7), flemiphilippinin E(8),5,7, 4'-trihydroxy-3'-methoxy-6, 8-dipre-nylisoflavone(9), 6, 8-dipreny naringenin(10), 5, 7, 4'-trihydroxy-6, 8-diprenylisoflavone(11), pomiferin(12), 5, 7, 3', 4'-tetra-hydroxy-6, 8-diprenylisoflavone (13), desmoxyphyllin A (14), 5, 7, 2', 4'-tetrahydroxy-8-(1, 1-dimethylprop-2-enyl) isoflavone (15), 5, 7, 4'-trihydroxy-2'-methoxy-isoflavone (16), Ψ-baptigenin (17), formononetin (18), quercetin (19), genistein (20) and genistin(21), respectively.

CONCLUSION:

Compounds 1, 4, 6, 14-17 are found from this genus for the first time.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2013 Type: Article