Inhibitory effect of traditional Chinese medicine Suifukang on the expression of chondroitin sulfate proteoglycans in cerebral ischemia zone of rats and glia scar cultured in vitro / 中国药学杂志

ABSTRACT

OBJECTIVE: To study whether the traditional Chinese medicine Suifukang can inhibit the expression of chondroitin sulfate proteoglycans(CSPGs) in rats with middle cerebral artery occlusion. METHODS: SD rats were selected and randomized into six groups: normal group, control group, methylprednisolone treatment group, and Suifukang high dose, middle dose and low dose treatment groups. Serum pharmacological method was used to prepare serum containing different concentrations of Suifukang. And glial scar model established in vitro was treated with the drug-containg serum. The expression of CSPGs was detected by immunohistology method. RESULTS: The expression of CSPGs in the injured brain and glial scar in vitro were significantly inhibited by Suifukang (P < 0.01). CONCLUSION: Suifukang can inhibit the expression of CSPGs. This function may be one of the mechanisms that Suifukang promotes the regeneration of axon and the functional recovery after ischemical injury of brain.