Application of humanized mice in drug metabolism and toxicity / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1137-1142, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-860300
ABSTRACT
OBJECTIVE:
To discuss the application of humanized mice model in drug metabolism and toxicity.METHODS:
By sorting foreign scientific literature, the history of the development of humanized mice model and its application in drug metabolizing enzymes and toxicity studies were reviewed and summarized to provide support for early drug development. RESULTS andCONCLUSION:
The humanized mice model could reduce interspecies differences and has been increasingly used in drug metabolism and safety evaluation in foreign countries. Transgenic mice can be applied to studying the metabolism of drugs metabolized by certain enzyme. In the chimeric mice body, the disposal of drugs could be more systematic and comprehensive mirrored, predicting this model has enormous potential in drug discovery and development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article
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