Systemic toxicity of (S)-(-)-pantoprazole sodium in rats following intravenous injection for 30 d / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1060-1064, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-860327
ABSTRACT
OBJECTIVE:
The systemic toxicities of S-(-)-pantoprazole sodium in rats following intravenous injuction for 30 d were studied.METHODS:
One hundred rats were divided randomly into 5 groups vehicle control group, pantoprazole sodium control group and three S-(-)-pantoprazole sodium groups with different dosages, and received vehicle, pantoprazole sodium(80 mg·kg-1·d-1), S-(-)-pantoprazole sodium(80, 40 and 20 mg·kg-1·d-1) by i.v.via tail vein. Administrations were performed each day for consecutive 30 d. Haematological parameters, biochemical parameters, and histopathology analysis were determined at 30 d of treatments and 14 d after the withdrawal, respectively.RESULTS:
The rats in the S-(-)-pantoprazole sodium group at 80 mg·kg-1·d-1 apperanced shortness of breath, unsteady gait, lying motionless and other symptoms. The levels of TC, Na+, Cl- in this group were significantly higher or lower than those in vehicle control group at 30 d(P<0.05), The change of these parameters regained to normal at 14 d after withdrawal.CONCLUSION:
Intravenous administration of the S-(-)-pantoprazole sodium for 30 d at high dose could induce reversible damage to liver and electrolyte. The toxicity of S-(-)-pantoprazole sodium is similar with pantoprazole sodium at the same dosage.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article
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