Evaluation of the phototoxicity of non-steroidal anti-inflammatory drugs by in vitro BALB/c 3T3 cytotoxicity method / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 912-915, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-860371
ABSTRACT
OBJECTIVE:
To evaluate the phototoxicity of several commonly used non-steroidal anti-inflammatory drugs by in vitro BALB/c 3T3 cytotoxicity method.METHODS:
The half inhibitory concentration (IC50) values of test articles with and without irritation were compared to calculate photo-irritation factor (PIF), then phototoxicity was judged based upon PIF values.RESULTS:
The PIF values of ketoprofen and naproxen were greater than 134.4 and 6.69, respectively, and that of fenbufen equaled to 5.96, all suggesting phototoxicity; ibuprofen and indometacin showed non-phototoxicity.CONCLUSION:
The results of this study are consistent with previous reports. It is verified that in vitro BALB/c 3T3 cell phototoxicity method has excellent predictability and suitability. Combining this method with other tests is believed as the inevitable trend to fully estimate the potential phototoxicity of compounds.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article
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