A network meta-analysis on the influence of antihypertensive agents on new-onset diabetes / 中国药学杂志

ABSTRACT

OBJECTIVE: To comprehensively evaluate the influence of antihypertensive agents on new-onset diabetes, including diuretics, beta-antagonists, angiotensin-converting enzyme inhibitors (ACEI), angiotensin II receptor blockers (ARB) and calcium channel blockers (CCB). METHODS: Clinical trials were searched about antihypertensive agents and NOD. The ORs and rankings of the five classes of drugs and placebo were estimated, using random effects Bayesian models in WinBUGS version 1.4.3. RESULTS: Twenty-eight clinical trials were included in this study. Compared to placebo, the ORs of the five classes of drugs for causing NOD were as follows ARB 1.23(95%CI1.087-1.399), ACEI 1.204(95%CI1.033-1.424), CCB 0.9289(95%CI0.7793-1.095), beta-antagonists 0.7384(95%CI0.6047-0.8906), diuretics 0.7894(95%CI0.654~0.9283). CONCLUSION: The probability of causing NOD is lowest for ARB followed by ACEI, placebo, CCB, diuretics and beta-antagonists. ARB and ACEI can reduce the risk of NOD. CCB, diuretics and beta-antagonists can increase the risk of NOD.