Research of determination methods of fluorouracil injection / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 558-561, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-860431
ABSTRACT
OBJECTIVE:
To confirm the best content determination method of fluorouracil injection.METHODS:
The contents of 95 batches of fluorouracil injection were determined by UV spectrophotometry absorption coefficient method and high performance liquid chromatography (HPLC), respectively. Through investigation of method recoveries, the reasons for difference in the content determination results were further analyzed.RESULTS:
The HPLC determination results were slightly higher than those of the UV method (P<0.05), The intervonversion of double alcohol type structure and double ketone type structure of fluorouracil might lead to the lower recovery and determination results of UV method.CONCLUSION:
The HPLC method is more accurate and reliable than UV method qualitatively and quantitatively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article
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