Determination of residual organic solvents in 2-2-methyl-4-2-4-(trifluoromethyl) phenyl pyrimidin-4-yl methylsulfanyl phenoxy acetic acid by capillary gas chromatography / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 562-564, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-860432
ABSTRACT
OBJECTIVE:
To establish a capillary GC method for the determination of residual solvents including ethanol, acetoni-trile, acetone, isopropanol, ethyl acetate, dioxane and THF in 2-[2-methyl-4-[[2-[4-(trifluoromethyl) phenyl] pyrimidin-4-yl] methylsulfanyl] phenoxy] acetic acid.METHODS:
The residual organic solvents were separated on DB-1capillary column (30 m × 0.53 mm, 5.00 μm). FID was used as detector with a temperature of 250°C, and the inlet temperature was 160°C. The carrier gas was nitrogen, and the column temperature was programmed set. The contents of residual solvents were calculated by external standard method.RESULTS:
The seven residual organic solvents were completely separated, the recovery rates and linear relationship were good, and three batches of samples all met the requirements.CONCLUSION:
The method is simple, accurate, and reproducible, so it can be used for the detection of seven residual organic solvents in the raw.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article
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