Effect of Kelong capsule on Ki-67, bFGF and VEGF mRNA expression in benign prostate hyperplasia tissues from rats / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the effect of Kelong capsule on kidney deficiency and blood stasis rats prostatic hyperplasia and the prostatic hyperplasia related protein and cell factors. METHODS: Establish rat model for benign prostate hyperplasia with kidney deficiency and blood stasis syndrome and observe rats prostate and prostate correlation factors of blank control (A), model (B), the finateride (C), high, medium and low dose kelong (D, E, F). RESULTS: (1) The prostate wet weight and prostate index of rats in groups C-F were significantly lower than that in group B (P<0.05). (2) Compared with group B, Ki-67integral optical density in prostate tissue obviously decreased in group C, E, F (P<0.01), group D has no significant difference (P≤0.05). (3) Compared with group B, bFGF integral optical density in prostate tissue in group C, D, E and F decreased obviously (P<0.01) but compared with group C, those in group D, E and F were significantly increased (P<0.05). (4) Compared with group B, VEGF mRNA expression in prostate tissue in group C, D, E and F were reduced (P<0.05). but those in group D, E and F were more than in C group (P<0.05). CONCLUSION: Kelong capsule can dose-dependently inhibit prostatic hyperplasia in rats possibly through the inhibition of prostatic hyperplasia related protein and cell factors.