Preparation and in vivo evaluation of glycgrrhizin acid-sodium deoxycholate/phospholipid-mixed micelles / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 280-285, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-860472
ABSTRACT
OBJECTIVE:
To improve the oral bioavailability of glycyrrhizin by preparing glyeyrrhizin-sodium deoxycholate/phos-pholipid-mixed micelles (GL-SDC/PL-MMs).METHODS:
GL-SDC/PL-MMs was prepared by a film dispersion method. In order toevaluate the property GL-SDC/PL-MMs comprehensively, physical and chemical properties determination, in situ intestinal absorption, and pharmacokinetics test were carried out.RESULTS:
The average particle size of drug-loaded micelles prepared by film dispersion method was (82.99±7.5) nm and Zeta potential was (-32.23±1.05) mV. Compared with the control drug, glycyrrhizin loaded in SDC/PL-MMs significantly improved its in situ intestinal absorption. The oral bioavailability was markedly enhanced, indicated by the increase of ρmax to 77.26 μg · mL-1, which was 2.82 times of that of the control drug.CONCLUSION:
SDC/PL-MMs is expected to be developed into a new drug delivery systems of GL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS