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Preparation of nimesulide solid dispersion by hot melt extrusion technology / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 185-190, 2013.
Article in Chinese | WPRIM | ID: wpr-860486
ABSTRACT

OBJECTIVE:

To improve the in vitro dissolution of nimesulide by preparing nimesulide solid dispersion with hot melt extrusion (HME) technology.

METHODS:

Using PVP-VA64, PVP K30 or PVA-PEG (Kollicoat IR) as hydrophilic carrier, nimesulide solid dispersion was prepared by hot melt extrusion and characterized by drug dissolution, DSC, XRD and FTIR.

RESULTS:

Nimesulide exhibited rapid in vitro dissolution from the solid dispersion using PVP-VA64 as carrier. The cumulative release rate was 81% in 10 min, much faster than its physical mixture (only 37% in 1 h). The results of DSC and FTIR showed that nimesulide was amorphously dispersed in the carrier.

CONCLUSION:

Hot melt extrusion technology is suitable for preparing nimesulide-PVP-VA64 solid dispersion, which can significantly increase drug dissolution.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2013 Type: Article