Simultaneous determination of ligustilide, senkyunolide I and other six components in Shunaoxin dropping pills by UPLC-Q-TOF-MS / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 216-219, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-860492
ABSTRACT
OBJECTIVE:
To establish an LC-MS method for simultaneous determination of six compounds (uridine, guanosine, ferulic acid, ligustilide, senkyunolide I and II in Shunaoxin dropping pills.METHODS:
The analysis was performed on a Waters Acquity BEH C18 column (2.1 mm × 100 mm, 1.7 μm) with the mixture of acetonitrile-water-formic acid as the mobile phase, and the flow rate was 0.4 mL · min-1; the PDA detection wavelength was 190-400 nm; the column temperature was room temperature (30°C).RESULTS:
The linear ranges for uridine, guanosine, ferulic acid, ligustilide, senkyunolide I and H were 10.31-206.24, 3.28-65.52, 6.36-127.24, 8.24-164.88, 10.18-200.52, and 3.14-62.72 μg · mL-1, respectively. The average recoveries were between 99%-101% (n=6).CONCLUSION:
This method is simple, accurate and reliable to determine the contents of the six compounds in Shunaoxin dropping pills for the quality control.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article
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