Compatibility between alkaloid extracts from Peganum harmala L. and different pharmaceutical excipients / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 43-48, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-860515
ABSTRACT
OBJECTIVE:
To study the compatibility between alkaloid extracts from P. harmala and different pharmaceutical excipients available in order to provide some references for tablet formulation design of the alkaloid extracts from Peganum harmala.METHODS:
The influence factor experiments combined with differential scanning calorimetry (DSC) and content determination of active components were used in the compatibility studies.RESULTS:
The alkaloid extracts were stable in the high temperature and strong light conditions. But the contents of the active components, harmine and harmaline, declined markedly with blocking in high moisture condition. The DSC fingerprints of the mixtures of alkaloid extracts and lactose/magnesium stearate changed manifestly in peak shape and peak position.CONCLUSION:
The total alkaloids from P. harmala are not suitable for storage in high moisture condition. And the pharmaceutical excipients of lactose and magnesium stearate would not be used with the total alkaloids from P. harmala in formulation. Copyright 2013 by the Chinese Pharmaceutical Association.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article
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