Population pharmacokinetics of doxapram in five different Chinese ethnic groups / 中国药学杂志

ABSTRACT

OBJECTIVE: To construct a population pharmacokinetic (PPK) model of doxapram in five different ethnic groups including Han, Mongolian, Korean, Hui and Uigur by NONMEM. METHODS: Fifty healthy volunteers were given a single dose of 50 mg doxapram intravenously. Blood samples were collected and determined by HPLC with a UV detector. Population pharmacokinetic model was constructed by NONMEM software. The influences of fixed-effect factors on the PK parameters were investigated. RESULTS: The following population parameters were estimated with a three-compartment model CL1 of 17.8 L · h-1, CL2 of 10.5 L · h-1, CL3 of 85.2 L · h-1, V1 of 17.4 L, V2 of 62.6 L, and V3 of 16.8 L. Ethnic group has a significant effect on V2, CL3 and CL1, while gender has a significant effect on CL2. CONCLUSION: The final PPK model of doxapram established by NONMEM is robust and reliable. It may be beneficial for the clinical use of doxapram. Copyright 2013 by the Chinese Pharmaceutical Association.