Physicochemical property and stability of zanamivir dry powder inhalation / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1911-1914, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-860544
ABSTRACT
OBJECTIVE:
To study the physicochemical property and stability of zanamivir dry powder inhalation (ZDI).METHODS:
ZDI was prepared by spray-drying method. The hygroscopicity, relative humidity, particle size, powder morphology, emptying rate and deposition rate of the inhalation were determined. Water contents were analyzed by TGA. The stability of ZDI was determined by accelerated test and long-term test.RESULTS:
The resultant powder inhalation exhibited the following properties critical relative humidity was 67%, and average aerodynamic diameter dae was 90%, and deposition rate was >30% for thress batches of samples; the accelerated test and the long-term test indicated that zanamivir dry powder inhalation was stable.CONCLUSION:
Zanamivir dry powder inhalation is stable and suitable for drug delivery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2012
Type:
Article
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