Preparation and in vitro release evaluation of metoprolol succinate sustained-release microcapsules / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare sustained-release microcapsules of metoprolol succinate(MS) and to investigate the influencing factors. METHODS: The sustained-release microcapsules of metoprolol succinate were prepared with ethyl cellulose(EC) in one step by the emulsion-solvent diffusion method. Uniform design was used to optimize the formulation and preparation technique. Its release behavior in vitro was studied. RESULTS: All microcapsules prepared under the optimum condition were spherical and smooth with the mean particle size in the range of 80-90 μm. The entrapment efficiency was 83.16% and drug release from the MS microcapsules during 18 h reached 96.1% in vitro. CONCLUSION: The microcapsules have good morphological characteristics, high entrapment efficiency and sustained-release effect in vitro.