Fish oil supplementation in critically ill patients: a systematic review / 中国药学杂志

ABSTRACT

OBJECTIVE: To evaluate the effect and safety of fish oil supplementation in critically ill patients. METHODS: Cochrane library, Cochrane Register of Controlled Trials, MEDLINE, EMbase, CNKI and Wanfang Data were searched for eligible literatures. The methodological quality of the included studies was evaluated and the data was analyzed by Revman5.0 software. RESULTS: Eleven high-quality randomized controlled trials were included. The quality of the eleven studies was evaluated according to Jadad scale, of which one scored four points, one scored five points, one scored six points, the others all scored seven points. The result of meta-analysis indicated that fish oil supplementation could reduce the length of stay in ICU and the time of ventilation(P < 0.00001), but it had no effect on mortality or the incidence of nosocomial infections. CONCLUSION: It is demonstrated that fish oil supplementation is effective and safe for critically ill patients. High-quality large-scale multiple-centered RCTs are required to confirm this finding.