The Efficacy of an Induction Chemotherapy Combination with Docetaxel, Cisplatin, and 5-FU Followed by Concurrent Chemoradiotherapy in Advanced Head and Neck Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 93-98, 2007.
Article
in English
| WPRIM
| ID: wpr-86059
ABSTRACT
PURPOSE:
This study was performed to determine the feasibility and safety of the use of induction chemotherapy combined with docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by concurrent chemoradiation therapy for locally advanced squamous cell carcinoma of the head and neck (SCCHN). MATERIALS ANDMETHODS:
The patients, that were initially not treated for locally advanced SCCHN, underwent three cycles of induction chemotherapy every 3 weeks at a dose of 70 mg/m2 docetaxel D1, 75 mg/m2 cisplatin D1, 1000 mg/m2 5-FU D1-4, and subsequently received concurrent chemoradiation therapy.RESULTS:
Forty-nine patients were enrolled in this study and forty-three of the patients completed the treatment. The median duration of follow-up was 18 months (range, 6~39 months). All of the patients had stage III (26.5%) or IV (73.5%) squamous cell carcinoma. After sequential therapy, a complete response and partial response was seen in 28 (65.2%) and 13 (30.2%) patients, respectively. The overall response rate was 95.4%. Overall survival and progression-free survival (PFS) at 2 years were 88.7% and 69.7%, respectively. Grade 3~4 neutropenia occurred in 42.2% of the patients and grade 4 thrombocytopenia in 1 cycle (0.7%). Two patients (4.1%) died during the induction chemotherapy due to pneumonia and a subdural hemorrhage, respectively. The group of patients over 65 years of age showed a significant lower dose intensity than that of patients under 65 years of age, but PFS was not significantly different between two groups (p=0.105).CONCLUSION:
TPF induction chemotherapy followed by concurrent chemoradiotherapy showed a high level of CR and moderate treatment-induced toxicity. Adequate dose modification in elderly patients should be considered to maintain efficacy and avoid treatment-related toxicity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Radiotherapy
/
Thrombocytopenia
/
Carcinoma, Squamous Cell
/
Follow-Up Studies
/
Cisplatin
/
Disease-Free Survival
/
Drug Therapy, Combination
/
Chemoradiotherapy
/
Induction Chemotherapy
Type of study:
Observational study
/
Prognostic study
Limits:
Aged
/
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2007
Type:
Article
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