Synthesis and cytotoxicity study of N-benzyl-3, 5-bis(arylmethylene)-4-piperidones / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1588-1591, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-860613
ABSTRACT
OBJECTIVE:
To synthesize a kind of novel cytotoxin with multi-drug-resistance reverting properties and study their cytotoxicity.METHODS:
The target compounds were obtained from N-benzyl-4-piperidones and benzaldehyde derivatives on the condition of 20°C, 7-8 h, taking dry hydrogen chloride as catalyst, using aldol condensation reaction, inspected by TLC and purified through recrystallization.RESULTS:
Five N-benzyl-3, 5-bis(arylmethylene)-4-piperidone derivatives were synthesized. The yield was over 49%. Their structures were characterized by 1H-NMR, ESI-MS with melting points. The data of cytotoxicity was obtained.CONCLUSION:
The synthetic route is convenient and efficient; The compounds had good inhibiting activity for a few kinds of tumor cells. Copyright 2012 by the Chinese Pharmaceutical Association.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2012
Type:
Article
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