Synthesis and anticancer activity study of diosgenin derivatives / 中国药学杂志

ABSTRACT

OBJECTIVE: To synthesize diosgenin derivatives and investigate their anti-tumor activities in vitro. METHODS: Designed and docked by AutoDock4.2, a series of diosgenin derivatives were selectively prepared from diosgenin. Their anti-tumor activities in vitro were evaluated for human malignant melanoma A375 cells, human lung adenocarcinoma A549 cells, human hepatoma HepG-2 cells and human myeloid leukemia K562 cells by MTT assay. RESULTS: Twelve novel compounds were synthesized and the basic structures were characterized by 1H-NMR and 13C-NMR. MTT assay showed that most of the diosgenin derivatives exhibited some anti-tumor activities. CONCLUSION: Most of the synthesized compounds had certain antitumor activity and showed no or little toxicity against the normal cells. Copyright 2012 by the Chinese Pharmaceutical Association.