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Synthesis and anticancer activity study of diosgenin derivatives / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 1407-1414, 2012.
Article in Chinese | WPRIM | ID: wpr-860638
Responsible library: WPRO
ABSTRACT

OBJECTIVE:

To synthesize diosgenin derivatives and investigate their anti-tumor activities in vitro.

METHODS:

Designed and docked by AutoDock4.2, a series of diosgenin derivatives were selectively prepared from diosgenin. Their anti-tumor activities in vitro were evaluated for human malignant melanoma A375 cells, human lung adenocarcinoma A549 cells, human hepatoma HepG-2 cells and human myeloid leukemia K562 cells by MTT assay.

RESULTS:

Twelve novel compounds were synthesized and the basic structures were characterized by 1H-NMR and 13C-NMR. MTT assay showed that most of the diosgenin derivatives exhibited some anti-tumor activities.

CONCLUSION:

Most of the synthesized compounds had certain antitumor activity and showed no or little toxicity against the normal cells. Copyright 2012 by the Chinese Pharmaceutical Association.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2012 Type: Article